Medicine is first line of treatment. With medicines, the disease comes under control (remission) in most of patients. There is possibility that symptoms may not improve or worsen despite treatment, and then next line of treatment is started. Surgery is reserved for its complications. Severity of disease decides the line of treatment.
Immunomodulators(Azathioprine & Cyclosporine)): These drugs are normally reserved for people who haven't responded well to other medications. Cyclosporine has the potential for serious side effects, such as kidney and liver damage, seizures, and fatal infections, and is not for long-term use.
BiologicsInfliximab (Remicade), adalimumab (Humira), Vedolizumab (Entyvio) and golimumab (Simponi): They block the inflammatory response of the body and help reduce the inflammation in the colon. They may be used if other medicines don't control your symptoms. These medicines are contra-indicated if there is any type on of infection in body like tuberculosis and active infections. These drugs also are associated with a small risk of developing certain cancers such as lymphoma and skin cancers.